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Gugle, Anil
- A Case Control Study of Metabolic Syndrome in Psoriasis Vulgaris Patients at Tertiary Care Institute
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MVP Journal of Medical Sciences, Vol 3, No 2 (2016), Pagination: 79-82Abstract
Background: Psoriasis is a chronic, disfiguring, inflammatory and proliferative condition of skin influenced by both genetic and environmental factors. The prevalence of psoriasis vary from 0.1% to 3% in different population1. The pathogenesis of psoriasis is interplay of various inflammatory cytokines and chemokines which play an important role in the pathogenesis of various other systemic diseases. Psoriasis has been reported to be associated with metabolic syndrome which increases the risk of Coronary Artery Disease. Aim: To study the prevalence of metabolic syndrome among patients of psoriasis vulgaris. Setting and Study Design: This is a case-control study and was conducted at the out-patient clinic of Department of Dermatology, Venereology and Leprology of a tertiary care centre. Materials and Methods: Study was approved by the Institutional ethical committee. The patients were included in two study groups. 50 patients diagnosed with psoriasis vulgaris were included as cases. Fifty age and sex matched controls were included in the control group. The detailed demographic history, duration of disease, family history and personal history was taken. Patients were assessed for severity of psoriasis using PASI score and blood sample collected was analyzed for fasting blood sugar levels and serum lipid profile. The data collected was evaluated using Chi Square test and unpaired t test. Results: Total 50 patients were included as cases and controls respectively out of which 11 (22%) were females and 39 (78%) were males. The mean age of cases and controls was 45.85 and 46.04 respectively. The mean duration of psoriasis in cases was 78.86 months. The mean PASI score was the prevalence of Metabolic Syndrome in psoriasis vulgaris was 46% in our study. Conclusion: Metabolic syndrome is a significant morbidity which predisposes the patients for Coronary Artery Disease. The patients of psoriasis vulgaris should be routinely screened for hypetension, Type II diabetes mellitus and dyslipidemias.Keywords
Dyslipidemia, Hypertension, Metabolic Syndrome, PASI Score, Psoriasis vulgarisFull Text
References
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- Griffiths CEM, Barker JNWN. Psoriasis. In: Tony B, Stephen B, Neil C, Christopher G, editors. Rook’s Textbook of Dermatology. 8th ed. Wiley-Blackwell; 2010. p. 20.1–20.54.
- Eckel RH. The metabolic syndrome. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison’s principles of internal medicine. 17th ed. Mc Graw Hill Publications; 2008. P. 1509–14.
- Madanagobalane S, Anandan S. Prevalence of metabolic syndrome in south Indian patients with psoriasis vulgaris and the relation between disease severity and metabolic syndrome: A hospital-based case-control study. Indian J Dermatol. 2012; 57:353–7.
- Nisa N, Qazi MA. Prevalence of metabolic syndrome in patients with psoriasis. Indian J Dermatol Venereol Leprol. 2010; 76:662–5.
- Belliappa PR, Umashankar N. Psoriasis uncovered-comorbid conditions with special reference to metabolic syndrome. Our Dermatol Online. 2014; 5(1):14–7.
- Love TJ, Qureshi AA, Karlson EW, Gelfand JM, Choi HK. Prevalence of the metabolic syndrome in psoriasis: Results from the national health and nutrition examination survey, 2003-2006. Arch Dermatol. 2011; 147:419–24.
- Armstrong AW, Harskamp CT, Armstrong EJ. Psoriasis and metabolic syndrome: A systematic review and meta-analysis of observational studies. J Am Acad Dermatol. 2012; 68(4):654–62.
- Cohen AD, Gilutz H, Henkin Y, Zahger D, Shapiro J, Bonneh DY, Vardy DA. Psoriasis and the Metabolic Syndrome. Acta Derm Venereol. 2007; 87:506–9.
- Dreiher J, Weitzman D, Davidovici B, Shapiro J, Cohen AD. Psoriasis and dyslipidemia: A population based study. Acta Derm Venerol. 2008; 88:561–5.
- Khunger N, Gupta D, Ramesh V. Is psoriasis a new cutaneous marker for metabolic syndrome? A study in Indian patients. Indian J Dermatol. 2013; 58:313–4.
- Clinical Profile and Patch Test Results among Hand Eczema Patients at a Tertiary Care Institute
Abstract Views :226 |
PDF Views:81
Authors
Affiliations
1 Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
2 Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital & Research Centre, Nashik - 422003, Maharashtra, IN
1 Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
2 Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital & Research Centre, Nashik - 422003, Maharashtra, IN
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MVP Journal of Medical Sciences, Vol 4, No 2 (2017), Pagination: 118-125Abstract
Background: Hand eczema is one of the most common dermatological disorders caused by various exogenous and endogenous factors. The condition that is frequently multifactorial, usually disabling or distressing to the sufferer, and often difficult to treat. Aims and Objectives: 1. To study the clinical profile among hand eczema patients. 2. To study the patch test results among hand eczema patients. Methodology: The present study was observational study, non-interventional, non-comparative conducted during October 2013 to December 2015 on 100 patients in OPD of Department of Dermatology at Dr. Vasantrao Pawar Medical College and Research Centre. A diagnosis was made by nomenclature proposed by Epstein. Patients were patch tested with the Indian Standard Battery approved by the Contact and Occupational Dermatoses Forum of India (CODFI). Results: 45 (45%) of patients gave a positive history to aggravation by a contact with detergents and soaps, and 25 (25%) patients for cement. 70 (70%) had bilateral involvement. Out of 100 patients patch tested, 70 patients (70%) gave positive patch test results, 30 patients (30%) were negative for patch test, 49 patients (49%) were sensitive to a single antigen and 21patients (21%) were sensitive to two antigens. Potassium dichromate was the most common sensitizer in male compared to female at the ratio of 2.2:1. Nickel sulfate was the most common sensitizer in females at the ratio of 0.07:1. Conclusion: Hyperkeratotic eczema and patchy vesiculosquamous type of hand dermatitis were the common patterns, but clinical patterns and specific allergen association was inconclusive.Keywords
Allergens, Hand Eczema, Patch Test.Full Text
References
- Wilkinson DS. Introduction, definition and classification.2nd ed. Hand Eczema. Menne T, Maibach HI, editors. New York: CRC Press; 2000. p. 1–13.
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- Bajaj AK. Contact dermatitis hands. Ind J Dermatol Venereol Leprol. 1983; 49(5):195–9. PMid:28176694.
- Epstein E. Hand dermatitis: Practical management and current concepts. J Am Acad Dermatol. 1984; 10:395–423.https://doi.org/10.1016/S0190-9622(84)80086-9.
- Warshaw EM, Ahmed RI, Belsito DV. Contact dermatology of the hands; cross sectional analyses of North American Contact Dermatitis Group Data 1994- 2004. J Am Acad Dermatol. 2007; 57:301-14. https://doi.org/10.1016/j.jaad.2007.04.016 PMid:17553593.
- Agrup G. Hand eczema. Acta Derma Venereol. 1969; 49:41– 7.
- Peltonen L. Nickel sensitivity in the general population.Contact Dermatitis 1979; 5:27–32. https://doi.org/10.1111/j.1600-0536.1979.tb05531.x PMid:421456.
- Kishore NB, Belliappa AD, Shetty NJ, Sukumar D, Rauis.Hand eczema – clinical patterns and role of patch testing.Ind J Dermatol Venereol Leprol. 2005; 71:207– 8. https:// doi.org/10.4103/0378-6323.16244.
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- Diepgen TL. Management of chronic hand eczema.Contact Dermatitis. 2007; 57:203–10.https://doi.org/10.1111/j.1600-0536. 2007.01179.x PMid:17868211 13.
- Sharma VK, Kaur S. Contact dermatitis of hands in Chandigarh. Ind J Dermatol Venereol Leprol. 1987; 53:103– 7.
- Beck MW, Wilkinson SM. Contact dermatitis: Allergic. 8th ed. Rook’s Textbook of Dermatology. Burns T, Breathnaeh S, Cox N, Griffiths C, editors. London: Blackwell; 2010. p.1–106.
- Hald M, Anger T, Blands J. Clinical severity and prognosis of hand eczema. Br J Dermatol. 2009; 160:1229–36. https:// doi.org/10.1111/j.1365-2133.2009.09139.xPMid:19416249.
- Lerback A, Kyvik KO, Ravn H. Clinical characteristics and consequences of hand eczema– An 8 year follow-up study of a population-based twin cohart. Contact Dermatitis. 2008; 56:210–6. https://doi.org/10.1111/j.1600-0536.2007.01305.x PMid:18353028.
- Skudli KC, Dulon M, Pohrt U. Osnabrueck hand eczema severity inde – A study of the interobserver reliability of a scoring system assessing skin diseases of the hands. Contact Dermatitis. 2006; 55:42–7. https://doi.org/10.1111/j.01051873.2006.00871.x PMid:16842554.
- Minocha YC, Dogra A, Sood VK. Contact sensitivity in palmar hyperkeratotic dermatitis. Ind J Dermatol Venereol Leprol. 1993; 59:60–3.
- Huda MM, Paul UK. Patch testing in contact dermatitis of hands and feet. Ind J Dermatol Venereol Leprol. 1996; 62:361-2. PMid:20948125.
- Jungbauer FHW, Lensen GJ, Gischolar_mainhoff JW, Coenroads PJ. Exposure of the hands to wet work in nurses. Contact Dermatitis. 2004; 50:225-9. https://doi.org/10.1111/j.01051873.2004.0314.x PMid:15186378.
- A Clinical and Histopathological Correlation among Leprosy Patients (in this Post Elimination Era) Attending Tertiary Referral Centre
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Authors
Affiliations
1 PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
2 Associate Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
3 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Institute of Medical Sciences and Research, Nashik – 422003, Maharashtra, IN
1 PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
2 Associate Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
3 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Institute of Medical Sciences and Research, Nashik – 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 6, No 2 (2019), Pagination: 103-108Abstract
Background: Leprosy is caused by Mycobacterium leprae, which chiefly affect skin and peripheral nerves. Leprosy expresses itself in different clinicopathological forms depending upon underlying immunity of the host. Histopathology is considered gold standard for accurate diagnosis especially in early disease, however, clinicopathological correlation is a must for appropriate diagnosis and classification of disease that will in-turn affect the treatment and overall prognosis of the patient. The present study of clinicohistopathological correlation among leprosy patients in this post elimination era was undertaken. Aims and Objectives: To study the clinical and histopathological correlation among leprosy patients. Materials and Methods: Present study consists of 54 patients of newly diagnosed leprosy cases at Department of Dermatology, Venerology and Leprology from November 2016 to October 2018. Skin punch biopsy and slit skin smear taken from patients. Histopathological examination by staining with H&E and Fite-Faraco stain for tissue AFB and Ziehl-Neelsen staining of SSS for presence of AFB. Results: In this study, 35 cases (64.81%) showed clinicohistopathological concordance and 19 cases (35.19 %) were discordant according to Ridley-Jopling spectrum. Conclusion: Histology should be performed in all suspected patients of leprosy if feasible, for exact allocation of the patient across the spectrum for accurate treatment and to identify the vulnerable patients in borderline spectrum as they are prone for reactions, neuritis and thus deformities and it also aids in achieving terminal goal of leprosy elimination.Keywords
Clinicohistopathological Concordance, Leprosy, Ridley-Jopling Classification.Full Text
References
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